April 28, 2026
Image credit: Tara Winstead, Pexels
04/24/2026
Perspective
Why obesity increases cancer risk has long remained a biological mystery. In this Perspective, Steven Moore and Patrick Ryan discuss rapid advances in statistical and analytical methods that are now opening the door to mechanistic discoveries that may finally help resolve this question.
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Browse Issues 2004 – 2026
04/28/2026
Policy Forum
This Policy Forum by Sebastian Walsh and colleagues outlines the principles and aims of the Population-Level Approaches to Dementia Risk Reduction (PLADRR) research group, an international network of researchers committed to investigating how structural, social, and environmental conditions can promote brain health and reduce dementia risk across the population.
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04/28/2026
Research Article
In a case-control study, Roxanne Hastie and colleagues set out to identify new prodromal symptoms of eclampsia, using cohorts in South Africa and Pakistan.
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04/23/2026
Research Article
Genetic mechanisms that predispose people to type 2 diabetes and cardiovascular disease remain poorly understood. In this genome-wide association study with Mendelian randomization, Madhusmita Rout and colleagues investigate associations between the human lipidome and cardiometabolic disorders.
Image credit: IMGMIDI, Pixabay
04/27/2026
Perspective
Dengue is a rapidly expanding global health threat driven by urbanization, climate change, and complex transmission dynamics. In this Perspective, Annelies Wilder-Smith details why modeling and tailored vaccination programs will be critical to developing effective, context-specific strategies to reducing disease burden.
Image credit: Mufid Majnun, Unsplash
04/24/2026
Research Article
Saeed Nemati and colleagues assess the potential impact of key policy interventions, including improving literacy rates, increasing tobacco taxation, and fully implementing the WHO MPOWER package, on tobacco-related cancer incidence in countries of the Eastern Mediterranean Region from 2025 to 2050.
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04/16/2026
Research Article
By Warittha Tieosapjaroen, Eloise Williams, and colleagues.
Image credit: National Institute of Allergy and Infectious Diseases, Unsplash
04/21/2026
Research Article
By Hwa-Young Lee and colleagues.
Image credit: Renkgezgini, Pexels
04/16/2026
Research Article
By Yifan Li, Vivien Kin Yi Chan and colleagues.
Image credit: TBIT, Pexels
04/16/2026
Research Article
By Andrew Yuen and colleagues.
Image credit: Myriam Zilles, Unsplash
In this Perspective article, Ann Weber and Gary Darmstadt discuss how benchmarking life expectancy against what is achievable reveals how sex disadvantage shifts by age, place, and time, and reframes inequality as unrealized potential due to social and structural constraints rather than differences in biology.
In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our PLOS Medicine Editor Philippa C. Dodd discuss the Special Issue dedicated to Antimicrobial resistance and emphasize the urgent threat of AMR.
Ruchita Balasubramanian and colleagues, estimate the incidence of hospital-associated infections resistant to antibiotics in 195 countries using point prevalence survey data.
James Neal Russell and colleagues explore antibiotic use and mortality prediction in hospitalised neonates and infants with sepsis.
Silvia Bertagnolio, Amitabh Bipin Suthar, Olga Tosas and Kitty Van Weezenbeek discuss surveillance of antimicrobial resistance, the existing limitations and the implications this has on accurate determination of incidence.
In this Special Issue, we present a fascinating array of research papers providing insights into various facets of mental health during the pandemic.
This collection of research articles highlights the multi-faceted challenges imposed by drug-resistant bacteria, the consequences for health and economics, and interventions that could lessen the burden.
In this Collection, PLOS Medicine presents high-quality translational research and clinical studies on advances in early cancer detection.
This Special Issue brings together the latest research on child and adolescent health, including strategies to monitor and combat child mortality from birth through adolescence, and environmental impacts on child health and mortality.
This 2019 Special Issue highlights the importance of nutrition for maternal and child health.
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